The Science Behind Active Again

The Science Behind Active Again

Active Again isn't just another joint supplement. It's backed by multiple peer-reviewed clinical studies published in respected medical journals. Here's the evidence.

5+

Published Clinical Studies

20+

Years of Use

0

Reported Side Effects

537ft

Further in 6-Min Walk

Peer-Reviewed Studies

Medical research and clinical equipment

Topical Cetylated Oils Quickly Improved Mobility in Painful Knee Arthritis

Journal of Rheumatology, Vol. 31, 2004 — Kraemer WJ, Ratamess NA, et al.

A randomised, double-blind, placebo-controlled trial of 40 adults with knee osteoarthritis. With cetylated fatty acid cream, everyday movements got easier and quicker, and knees moved more freely. Relief showed up within 30 minutes and kept building over 30 days.

Key Results:
  • Significantly faster stair-climbing and Timed Up-and-Go times at 30 minutes and 30 days
  • Increased knee range of motion
  • Greater gains in balance for both legs vs placebo

Oral Cetylated Fatty Acids Improved Knee Flexion and Function

Journal of Rheumatology, Vol. 29, 2002 — Hesslink RL Jr, Armstrong D, et al.

A randomised, double-blind, placebo-controlled trial of 64 adults with chronic knee osteoarthritis over 68 days. People taking oral CFA bent their knees further, moved with more confidence, and reported better function.

Key Results:
  • 10° increase in knee flexion vs ~1° for placebo
  • Lequesne scores improved -5.4 points vs -2.1 for placebo
  • More patients reported less pain and reduced swelling

Oral Cetylated Oils Increased Walking Distance and Reduced Knee Pain

Scripps Integrative / Medicus Research, 2007 — Udani JK, Singh B, et al.

Randomised, double-blind, placebo-controlled trial of 93 adults with moderate knee osteoarthritis over 8 weeks. Patients taking oral CFA walked hundreds of feet farther in six minutes while pain scores dropped significantly.

Key Results:
  • CFA group walked +537 ft further at 8 weeks vs -106 ft for placebo
  • Knee pain decreased significantly on all four VAS pain items
  • No adverse events reported

One Week of CFA Cream Eased Symptoms in Early and Advanced Knee OA

Archives of Rheumatology, Vol. 33(4), 2018 — Ariani A, Parisi S, et al.

A multi-centre study of 113 adults with confirmed knee osteoarthritis. With just one week of twice-daily CFA cream, patients reported less pain, less stiffness, and better function — even with advanced joint damage.

Key Results:
  • Significantly reduced WOMAC scores for pain, stiffness, and physical function
  • Symptom relief in both early and advanced osteoarthritis

CFA Cream With Menthol Eased Arthritis Pain and Boosted Performance

Journal of Strength and Conditioning Research, Vol. 19(2), 2005 — Kraemer WJ, et al.

28 adults with arthritis of the knee, elbow, or wrist used CFA + menthol cream for one week. Patients climbed stairs faster, walked more easily, and showed stronger endurance — all while reporting less pain.

Key Results:
  • Stair-climbing and mobility improved ~12% in one week
  • Balance/strength improved ~16.5%
  • Muscular endurance increased 22–42% in elbow/wrist arthritis

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